InformationGSK3145095 GSK3145095 is a potent and orally active RIP1 kinase inhibitor with IC50 of 6.3 nM with potential antineoplastic and immunomodulatory activities.TargetsRIP1 kinase (Cell-free assay) 6.3 nMIn vitroGSK3145095 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking RIP1 kinasedependent cellular responses. Highlighting its potential as a novel cancer therapy, the inhibitor is also able to promote a tumor suppressive T cell phenotype in pancreatic adenocarcinoma organ cultures.Cell Research(from reference)Cell lines：U937 cells, L-cells NCTC 929 (L929) cells Concentrations：0-3 μM Incubation Time：5 h. Specification: 0.99 Molecular Formula: C20H17F2N5O2 Molecular Weight: 397.38 PubChem CID: 118557502 Isomeric SMILES: C1CC2=C(C(=CC(=C2)F)F)NC(=O)[C@H]1NC(=O)C3=NNC(=N3)CC4=CC=CC=C4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/G414217-SCI_19217a330174fc540a13bccc8863ad32.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G414217-10mg
- CAS:
- 1622849-43-7
- Product Size:
- 10mg
