InformationGSK620 GSK620 is a pan- BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.TargetsBD2In vitroGSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 is capable of reducing the MCP-1 response in a concentration-dependent manner, providing strong evidence that GSK620 is indeed engaging BD2 in cells.In vivoGSK620 is a potent and selective pan-BD2 inhibitor with excellent in vivo PK properties and excellent developability properties, with the exception of moderate FaSSIF solubility driven by its highly crystalline nature.Cell Research(from reference)Cell lines：human whole blood, hepatocytes Concentrations：0.5 μM Incubation Time：60 min, 120 min. Specifications and Purity: 10mM in DMSO. Molecular Formula: C18H19N3O3. Molecular Weight: 325.36. PubChem CID: 126648559. Isomeric SMILES: CNC(=O)C1=CC(=CN(C1=O)CC2=CC=CC=C2)C(=O)NC3CC3.
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G422531-1ml
- CAS:
- 2088410-46-0
- Product Size:
- 1ml
