GSK8612 (C15-1722-005)

Sigma Aldrich

Catalog No.: C15-1722-005
Manufacturer No.: SML2721-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Price: $1,092.72

List Price: $1,214.14

Biochem/physiol Actions GSK8612 is a potent and highly selective tank-binding kinase-1 (TBK1) inhibitor (pIC 50 = 6.8: pK d = 8.

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Description
Specifications

Biochem/physiol Actions

GSK8612 is a potent and highly selective tank-binding kinase-1 (TBK1) inhibitor (pIC₅₀ = 6.8; pK_d = 8.0 vs pK_a = 6.2/STK17B, 6.0/IKKε, 6.1/LRRK2, 6.0/FLT4, 5.8/ULK3, 5.7/BMP2K, 5.7/CSNK2A1, 5.6/CSNK2A2, 5.6/FLT4, 5.5/PIK3CD, <5.5/more than 270 kinases). GSK8612 inhibits IFNβ secretion induced by dsDNA containing virus or STING ligand cGAMP (IC₅₀ = 1.25 & 0.5 μM, respectively; THP-1), as well as suppresses TLR3 ligand poly(I:C)-induced IRF3 Ser396 phosphorylation (IC₅₀ = 1 μM; Ramos) and IFNα release (IC₅₀ = 0.79 μM; human PBMCs), a IFN positive feedback response steming from IFNβ.

UPC:: 42172008
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: SML2721-25MG
Product Size:: 25/MG
CAS:: 2361659-62-1

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