GSK9311, a less active analogue of GSK6853, can be used as a negative control. GSK9311 inhibits BRPF bromodomain with pIC 50 values of 6.0 and 4.3 for BRPF1 and BRPF2 , respectivelyIn VitroGSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain, and demonstrates properties suitable for cellular and in vivo studies. GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:BRPF1 6.0 (pIC 50 ) BRPF2 4.3 (pIC 50 ). Specification: 0.99 Molecular Formula: C24H31N5O3 Molecular Weight: 437.53 PubChem CID: 121232406 Isomeric SMILES: CCN(C1=C(C=C2C(=C1)N(C(=O)N2C)C)N3CCNC[C@H]3C)C(=O)C4=CC=CC=C4OC
- UPC:
- 51202200
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G646258-10mg
- CAS:
- 1923851-49-3
- Product Size:
- 10mg
