GT949 (C005B-310049)

Catalog No.: C005B-310049
Mfr. No.: SML2823-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $227.17

List Price: $252.41

Biochem/physiol Actions GT949 is a potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2 (glutamate uptake EC 50 = 0.26 nM: COS-7 EAAT2 transfectant), but not EAAT1 or EAAT3.

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Description
Specifications

Biochem/physiol Actions

GT949 is a potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2 (glutamate uptake EC₅₀ = 0.26 nM; COS-7 EAAT2 transfectant), but not EAAT1 or EAAT3. GT949 enhances glutamate uptake of cultured rat astrocytes (EC₅₀ = 1 nM, E_max = 158%) with no potency toward human serotonin (SERT), noradrenaline (NET) and dopamine (DAT) transporters, nor NMDA receptors (murine primary cortical neurons).

UPC:: 51422509
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2823-5MG
CAS:: 460330-27-2

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