Guanidine thiocyanate is a chaotropic agent that functions as a strong protein denaturant. It is widely used in RNA isolation protocols. Guanidine thiocyanate can irreversibly inactivate RNase and DNase and breaks cellular membranes. It dissolves proteins by disturbing their secondary structures. Guanidine thiocyanate also separates nucleoproteins from nucleic acids and aids the digestion of the proteins with proteases. It improves the activity of proteinase K thus making it the protease of choice.Application:Guanidine thiocyanate solution has been used to extract: plasma RNA from human immunodeficiency virus (HIV)-infected and control patientstotal RNA from collected tissues (shoots, flowers, fruits, and seeds)in reverse transcription-polymerase chain reaction (RT-PCR) analysis, RNA from teratocarcinoma cell line (Tera-1)
Specification: BioUltra, for molecular biology, ~6 M in H2O
MDL Number: MFCD00013027
Molecular Formula: C2H6N4S
Molecular Weight: 118.16
EC Number: 209-812-1
PubChem CID: 65046
Isomeric SMILES: C(#N)S.C(=N)(N)N
Beilstein Registry Number: 3563461
- UPC:
- 41106311
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 0.31 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G755743-50ml
- CAS:
- 593-84-0
- Product Size:
- 50ml
- Hazard Statement Codes:
- H302+H312+H332:H332:H312:H318:H302:H412:H314
