General description
A metabolically-stable, competitive inhibitor of protein kinase G type Iα and Iβ (Ki = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC50 = 25 µM). Also reported to block the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µmol = 2.81 mg.
A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µM) and the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKG1α & 1β
Product does not compete with ATP.
Reversible: no
Target Ki: 30 nM against PKG1α & 1β
Warning
Toxicity: Standard Handling (A)
Other Notes
Wei, J.Y., et al. 1996. Biochemistry35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51102830
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 370679-1UMOL
