Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, beta-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem

General description

A metabolically-stable, competitive inhibitor of protein kinase G type Iα and Iβ (K_i = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 µM). Also reported to block the activation of purified PKA type II (K_i = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µmol = 2.81 mg.

A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (K_i = 30 nM). Blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 µM) and the activation of purified PKA type II (K_i = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKG1α & 1β

Product does not compete with ATP.

Reversible: no

Target K_i: 30 nM against PKG1α & 1β

Warning

Toxicity: Standard Handling (A)

Other Notes

Wei, J.Y., et al. 1996. Biochemistry35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.

Legal Information

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