Application

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:

as a component of lysis buffer
in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state
to couple with G- protein α, to study its effect on kinase activity

Biochem/physiol Actions

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

Features and Benefits

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