The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists, including 15-deoxy-.DELTA.12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
More Information: https://cenmed.com/shipping-returns
- UPC:
- 51183705
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 70785-1
- CAS:
- 22978-25-2
- Model Number:
- C837N48
- Temperature Control Device:
- Yes
