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gw7647

GW7647

Catalog No.
C15-1226-982
Manufacturer No.
G6793-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG
Price: $1,633.71
List Price: $1,815.24

Application GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand: in defatting medium to treat primary human hepatocytes to test its effect on the glycolytic function in cardiomyocytes to test its effect

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Application

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:

  • in defatting medium to treat primary human hepatocytes
  • to test its effect on the glycolytic function in cardiomyocytes
  • to test its effect on infant mouse heart
  • in breast cancer MDA-MB-231 cells to activate PPARs

Biochem/physiol Actions

GW7647 reduces serum triglyceride levels and enhances hepatic expression of genes associated with β-oxidation. Usage of GW7647 along with metformin in conditions of liver steatosis or injury improves the enzymatic levels of aspartate transaminase (AST) and alanine transaminase (ALT) in serum.

Potent human PPARα agonist. Use to study the biology of PPARα receptor in human cells.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold for research purposes only under agreement from Glaxo­Smith­Kline

UPC:
41115700
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
G6793-25MG


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