Gypenoside LI

Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis , cell cycle and migration.In VitroGypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells. Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells. Gypenoside LI could obviously suppress the expression of CDK1 protein rather than/nCDK2 and CDK4 proteins. Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells. Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway. Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A549 cells. Concentration: 0-80 μM. Incubation Time: 24 h. Result: Displayed the strongest activity with the IC 50 values of 21.36 ± 0.78 μM.Form:Solid. Specifications and Purity: 98%. Molecular Formula: C42H72O14. Molecular Weight: 801.01. PubChem CID: 76317290. Isomeric SMILES: CC(=CCC[C@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(C[C@H]([C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)O)C)C)O)C)O)C.