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HA-1077 dihydrochloride (C15-1222-278)

Catalog No.
C15-1222-278
Manufacturer No.
H139-5MG
Manufacturer Name
Sigma-Aldrich
Quantity
5
Unit of Measure
MG
Price: $690.86
List Price: $767.62

Application HA-1077 dihydrochloride has been used: to relax cantilevers in the functional assessment of isolated coronary arteries to investigate the effect of azaindole-1, fasudil on acute hypoxic pulmonary vasoconstriction (HPV) Biochem/physiol

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Application

HA-1077 dihydrochloride has been used:

  • to relax cantilevers
  • in the functional assessment of isolated coronary arteries
  • to investigate the effect of azaindole-1, fasudil on acute hypoxic pulmonary vasoconstriction (HPV)

Biochem/physiol Actions

HA-1077/fasudil, is a Rho kinase inhibitor. This ROCK inhibitor has the ability to increase cognitive deficits in animals, that have Alzheimer′s disease (AD). In humans, fasudil possesses high therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH). HA-1077 also acts as an inhibitor of protein kinases, like myosin light chain kinase and Rho associated kinase. Hence, it can block myosin phosphorylation.

Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist.

UPC:
51472806
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
H139-5MG


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