HBX 41 108 (C15-1720-818)

Catalog No.: C15-1720-818
Mfr. No.: SML3415-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $177.34

List Price: $197.04

Biochem/physiol Actions HBX 41,108 is a catalytic site-targeting, uncompetitive, potent and reversible ubiquitin-specific protease (USP) inhibitor (USP7/HAUSP IC50 = 420 nM) with little potency toward aspartic, serine or other non-USP cysteine

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Description
Specifications

Biochem/physiol Actions

HBX 41,108 is a catalytic site-targeting, uncompetitive, potent and reversible ubiquitin-specific protease (USP) inhibitor (USP7/HAUSP IC50 = 420 nM) with little potency toward aspartic, serine or other non-USP cysteine proteases. HBX 41,108 exhibits antiproliferation potency in cancer cultures (HCT116 GI50 = 1 μM post 24 h treatment) by preventing USP7-mediated p53 deubiquitination and thereby promoting p53 target genes expression and inducing p53-dependent apoptosis.

UPC:: 12352200
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3415-5MG
CAS:: 924296-39-9

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