HC-067047 (C005B-313734)

Catalog No.: C005B-313734
Mfr. No.: SML0143-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $267.54

List Price: $297.26

Application HC-067047 :has been used as a transient receptor potential cation channel subfamily V member 4 (TRPV4) :inhibitor: to study its effects on organoid formation and proliferation in human endometrial tissues to determine its

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Description
Specifications

Application

HC-067047 has been used as a transient receptor potential cation channel subfamily V member 4 (TRPV4) inhibitor:

to study its effects on organoid formation and proliferation in human endometrial tissues
to determine its effects on neuronal survival after intracerebral hemorrhage (ICH)
to study its effects on TRPV4 regulation of angiotensin II receptor type 1 (AT1R) task, phosphorylation and β-arrestin recruitment in choroid plexus

Biochem/physiol Actions

HC-067047 is a potent, selective inhibitor of hTRPV4. The compound inhibits human, rat and mouse TRPV4 with IC₅₀ values of 48, 133 and 17 nM, respectively. HC-067047 does not inhibit other TRPV isoforms at concentrations up to 5 μM. HC-067047 inhibits hERG channel and the menthol receptor TRPM8 with IC₅₀ values of 370 and 780 nM, respectively.

UPC:: 51373447
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML0143-5MG
CAS:: 883031-03-6

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