General description
HCK (hematopoietic cell kinase), a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells. It is especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes.
Biochem/physiol Actions
HCK (hematopoietic cell kinase) gene is mapped to human chromosome 20q11-q12. This region on the chromosome urdergoes interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders, thereby suggesting HCK participation in the pathogenesis of these conditions.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC
- UPC:
- 51314331
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- H2915-10UG
