General description
A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.
A benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Hsp70
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Harmful (C)
Reconstitution
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.
Other Notes
Koishi, M., et al. 2001. Clin. Cancer Res.7, 215.
Yokota, S., et al. 2000. Cancer Res.60, 2942.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 12352200
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 373260-5MG
