Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 is a cell-permeable thiazolyl benzamide compound that preferentially targets Hec1, disrupts Hec1/Nek2 complex, and destabilizes Nek2 leading to defective localization of Hec1 at kinetochores. Shown to induce transient mitotic arrest, and inhibit the proliferation of several breast cancer cells with a GI|50|of 10 - 21 μM; further, reduce tumor outgrowth in a xenograft mouse model (50 mg/kg, i.p.). Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 is an inhibitor of Hec1.Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1is a compound able to induce transient mitotic arrest. Molecular Formula: C18H16N2OS Molecular Weight: 308.4 PubChem CID: 959043 Isomeric SMILES: CC1=CC(=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=CC=C3)C Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/H386140-SCI_b502be7ee7e98e79d1688eea1e7bfe13.pdf
- UPC:
- 12352200
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- H386140-10mg
- CAS:
- 313553-47-8
- Product Size:
- 10mg
- Precautionary Statement Codes:
- P264
