Hemoglobin A0, Ferrous Stabilized human (C15-1247-740)

General description

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.

Application

Hemoglobin A0, ferrous stabilized human has been used:

• as the non-fluorescent absorber in the preparation of tissue-mimicking phantoms
• to see how coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype
• to study the interference of hemoglobin (Hb) A0, HbA2, and HbS in the assay of HbF

Hemoglobin A₀ was used to see how coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. It was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.

Biochem/physiol Actions

Variation in the haemoglobin (Hb) encoding genes results in haemoglobinopathies such as thalassaemia and atypical structural variants like Hb Lepore and HbE.

Packaging

Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).

Reconstitution

When reconstituted with buffer, gives >85% ferrous hemoglobin.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.