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HISTONE H2B HUMAN RECOMBINANT EXPRESSED IN <(><<)>I>ESCHERICHIA COLI <(><<)>/I>

Catalog No.
C005B-019662
Mfr. No.
H2167-100UG
Mfr. Name
Sigma-Aldrich
Qty/UOM
100
UOM
UG
Price: $276.92
List Price: $307.69

Histones are highly basic chromatin proteins. They tightly organize eukaryotic DNA into nucleosomes.

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General description

Histones are highly basic chromatin proteins. They tightly organize eukaryotic DNA into nucleosomes. A nucleosome exists as an octameric core histone comprising a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B, wherein the 147 DNA base pairs are wrapped around the histone complex.

Application

Histone H2B human has been used in far western blot analysis.

Biochem/physiol Actions

Histones are known to regulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. Extrachromosomal histone H2B functions as a cytosolic sensor and detects the double-stranded DNA (dsDNA) fragments produced from infectious agents or damaged cells. This stimulates innate and acquired immune responses in different cell types. Histone H2B moves in and out of the nucleosome more quickly than other core histones.

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UPC:
41105328
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
H2167-100UG
CAS:
1523001-32-2
Temperature Control Device:
Yes

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