HOIPIN-8 (C09-1138-601)

HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC 50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-αAppearance:SolidIn Vitro:HOIPIN-8 (0-100 μM；72 hours) 对 A549 细胞几乎没有细胞毒性，IC 50 值为 100 μM。 HOIPIN-8 (0-10 μM；24 hours) 对 NF-κB 活化的抑制作用比 HOIPIN-1 高 10 倍以上，IC 50 值为 0.42 μM HEK293T细胞。 HOIPIN-8 (0-30 μM；NF-κB荧光素酶报告基因转染细胞18小时；然后用10 ng/mL TNF-α转染6小时h) 比 HOIPIN-1 效力提高4倍，IC 50 值Biological Activity:HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC 50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α. Specification: ≥95% Molecular Formula: C23H15F2N4NaO3 Molecular Weight: 456.38