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HPN-01 (C09-1138-554)

Aladdin

Catalog No.
C09-1138-554
Manufacturer No.
H655642-1ml
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $425.44
List Price: $472.71

HPN-01 is a potent and selective IKK inhibitor, with pIC 50 values of 6.4, 7.0 and <:4.8 for IKK-α , IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5 , CDK-2,

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HPN-01 is a potent and selective IKK inhibitor, with pIC 50 values of 6.4, 7.0 and <4.8 for IKK-α , IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5 , CDK-2, EGFR , ErbB2, GSK3β, PLK1 , Src , and VEGFR-2In VitroHPN-01 effectively suppress LPS-stimulated secretion of TNF-α, IL-1β, and IL-6 from human PBMCs (pIC 50 =6.1, 6.4, and 5.7, respectively). HPN-01 also inhibits TNF-α-induced NF-κB nuclear translocation in human lung fibroblast cells (pIC 50 =5.7). HPN-01 inhibits the expression of SREBP-1and SREBP-2 in cultured primary human hepatocytes with IC 50 s of 1.71 μΜ and 3.43 μΜ, respectively. HPN-01 is being development for the treatment of nonalcoholic fatty liver disease (NAFLD). MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:IKK-α 6.4 (pIC 50 ) IKK-β 7.0 (pIC 50 ) IKK-ε <4.8 (pIC 50 ). Specification: 10mM in DMSO Molecular Formula: C19H16ClN3O3S Molecular Weight: 401.87
UPC:
12352005
Condition:
New
Availability:
8-12 weeks
Weight:
1.06 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
H655642-1ml
CAS:
928655-63-4
Product Size:
1ml


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