hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC 50 of <0.05 nM. hSMG-1 inhibitor 11e shows >900-fold selectivity over mTOR (IC 50 of 45 nM), PI3Kα/γ (IC 50 s of 61 nM and 92 nM) and CDK1/CDK2 (IC 50 s of 32 μM and 7.1 μM)In VitrohSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:hSMG-1 <0.05 nM (IC 50 ) mTOR 45 nM (IC 50 ) PI3Kα 61 nM (IC 50 ) PI3Kγ 92 nM (IC 50 ) CDK1 32 μM (IC 50 ) CDK2 7.1 μM (IC 50 ). Specifications and Purity: 99%. Molecular Formula: C26H27N7O3S. Molecular Weight: 517.60. PubChem CID: 71458574. Isomeric SMILES: CC1=C(C=C(C=C1)NC2=NC=CC(=N2)C3=CC(=NC=C3)C4=CC=C(C=C4)NC(=O)NC)S(=O)(=O)N(C)C.
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- H650955-10mg
- CAS:
- 1402452-10-1
- Product Size:
- 10mg
