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HSP70-IN-1 (C09-1138-203)

Aladdin

Catalog No.
C09-1138-203
Manufacturer No.
H648852-5mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $510.30
List Price: $567.00

HSP70-IN-1 is a heat shock protein ( HSP ) inhibitor: inhibits the growth of Kasumi-1 cells with an IC 50 of 2.3 μM.In VitroThe heat shock protein 70 (Hsp70) is a molecular chaperone which plays an important function in protein homeostasis as well

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HSP70-IN-1 is a heat shock protein ( HSP ) inhibitor; inhibits the growth of Kasumi-1 cells with an IC 50 of 2.3 μM.In VitroThe heat shock protein 70 (Hsp70) is a molecular chaperone which plays an important function in protein homeostasis as well as in cell signaling and survival. Hsp70 is frequently overexpressed in cancer, where the elevated expression is furthermore believed to be a cause of or to lead to resistance to chemotherapy and other treatments. HSP70-IN-1 interferes with the formation of functional Hsp70-HOP-Hsp90 machinery by its ability to dose-dependently alter the megacomplex components and to destabilize an Hsp70-Hsp90 machinery client, Raf-1. In cells, the refolding of heat-denatured luciferase by endogenous as well as transfected Hsp70 is inhibited by HSP70-IN-1. HSP70-IN-1 also results in induction of apoptosis in cancer cells. Addition of HSP70-IN-1to cancer cells dose-dependently alters the formation of the Hsp70-HOP complex, a phenomenon associated with their destabilization and reduction in half-life. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:HSP70 Caspase-3/7 1.9 μM (IC 50 , MOLM13 cells). Specification: 0.98 Molecular Formula: C24H28N6O2S Molecular Weight: 464.58 PubChem CID: 66973893 Isomeric SMILES: CN1CCN(CC1)C2=NC=C(C(=N2)OCC3=CC=CC=C3)SC4=CC=CC(=C4)NC(=O)CN
UPC:
12352208
Condition:
New
Availability:
8-12 weeks
Weight:
1.06 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
H648852-5mg
CAS:
1268273-90-0
Product Size:
5mg

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