Human Growth Hormone (GH), 1mg

GH, Growth Hormone, human: Human Growth Hormone Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretary granules. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones-GH-releasing hormone (GHRH) and somatostatin (SST) - as well as by signals from the periphery - ghrelin and leptin.4. The human GH cDNA encodes a 217 amino acid (aa) residue precursor protein with a 26 aa putative signal peptide. By alternative splicing, at least four isoforms of GH have been identified. Source: Escherichia coli. Molecular Weight: Approximately 22 kDa, a single non-glycosylated polypeptide chain containing 191 amino acids Quantity: 20ug, 100ug and 1.0 mg AA Sequence: FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F Purity: >96% by SDS-PAGE and HPLC analyses. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by the assay of the proliferation of the rat lymphoma, NB2-11 was found to be less than 0.1 ng/ml. Formulation: Lyophilized from a 0.2mm filtered concentrated solution with 5mM NaHCO3, pH 7.0 Endotoxin: Less than 1EU/mg of rHuGH as determined by LAL method.