General description
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HUVSMC has been used in studies evaluating treatments that involve blood vessel stents. Specifically, intra-shunt delivery of motexafin gadolinium was shown to inhibit the proliferation of SMCs during treatment of portal hypertension (Wang, 2013). Also, high-density lipoproteins (HDL) exhibit cardioprotective and anti-inflammatory properties by reducing HUVSMC expression of chemokines CCL2, CCL5, and CX3CL1, and chemokine receptors CCR2 and CX3CR1 (via NF-κB/pAkt inhibition) and by decreasing cell proliferation (via pERK inhibition), highlighting HDL importance in preventing neointimal hyperplasia, the main cause of early vein graft/stent failure (van der Vorst, 2013). HUVSMC were also used to demonstrate that genes coding for muscle and non-muscle actin proteins are transcribed by different transcription machinery (Lee, 2011).Characterization: positive for smooth muscle cell specific alpha-actin expression.
Cell Line Origin
Vein
Application
cell adhesion, pharmacology, vascular therapy research, coagulation, drug discovery, regulation of vascular tone
Components
Smooth Muscle Cell Basal Medium containing 10% FBS & 10% DMSO
Preparation Note
- 2nd passage, >500,000 cells in Smooth Muscle Cell Basal Medium containing 10% FBS & 10% DMSO
- Can be cultured at least 6 doublings
Subculture Routine
Please refer to the HUVSMC Culture Protocol.
biological source: human umbilicus (normal veins). Quality Level: 100. packaging: pkg of 500,000 . cells. manufacturer/tradename: Cell Applications, Inc. growth mode: Adherent. karyotype: 2n : 46. morphology: smooth muscle. technique(s): cell culture | mammalian: suitable. relevant disease(s): cardiovascular diseases. shipped in: dry ice. storage temp.: −. 196°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 12352206
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 250-05N