Humanin (C09-1138-058)

Humanin, an anti-apoptotic peptide of 24 amino acids , is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG .In VitroHumanin (40 nM, rhodamine-conjugated; 30 min) inhibits cell death induced by Bax protein in wild-type HCT116 cells. Humanin (100 μM; 10 min) blocks Bax association with isolated mitochondria, and suppresses cytochrome c release in wild-type HCT116 cells. Humanin reduces half apoptosis induced by 0.2 mM STS. Humanin fails to suppress apoptosis in Bax-deficient HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoHumanin (0.375 mg/kg/hr; i.v.) increases peripheral insulin sensitivity in Zucker diabetic fatty (ZDF) rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Bax. Specifications and Purity: ≥95.0%. Molecular Formula: C119H204N34O32S2. Molecular Weight: 2687.23. PubChem CID: 16131438. Isomeric SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)[C@H](CCSC)N.