Recombinant Human Interferon gamma (IFN γ), is a cytokine also known as type II interferon that provides immunity against bacterial, viral and protozoan infections. In its active form, IFN γ occurs as a glycosylated, non-covalently linked homodimer of 29-32 kDa subunits. It is produced by a number of immune cell types such as the natural killer cells, natural killer T cells, and effector lymphocyte T cells following antigenic and inflammatory triggers. Following secretion, the IFN γ dimer binds to its receptor which has two subunits: IFN-γR1 which is the ligand-binding chain (α chain) and IFN-γR2, the signal-transducing chain (β chain). The activation of the IFN γ receptor leads to activation of the JAK/STAT pathway which in turn activates IFN γ responsive genes. While IFN γ can inhibit viral replication, it also works as an immune-modulator and immune-stimulator by increasing surface expression of class I MHC proteins.
- UPC:
- 12350000
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- HZ-1301-100
