Application
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
Other Notes
Recruiting cytotoxic T cells to folate-receptor-positive cancer cells
Syntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technology
High density orthogonal surface immobilization via photoactivated copper-free click chemistry
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
- UPC:
- 51111906
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 902586-1G
