Biochem/physiol Actions Hydroxy-α:-sanshool is an active ingredient in Szechuan peppers (also present in other Zanthoxylum plants) that produces a tingling paresthesia or numbing effects. Hydroxy-α:-sanshool is a potent agonist of
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Hydroxy-α-sanshool is an active ingredient in Szechuan peppers (also present in other Zanthoxylum plants) that produces a tingling paresthesia or numbing effects. Hydroxy-α-sanshool is a potent agonist of TRPV1/TRPA1 as well as antagonist/blocker of KCNK3/KCNK9/KCNK18 channels. It induces colonic motor activity in rat proximal colon.
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