Hypophyllanthin is a major lignan in Phyllanthus spp , with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activityIn VitroHypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:P-gp. Specification: 0.98 Molecular Formula: C24H30O7 Molecular Weight: 430.49 EC Number: 803-418-9 PubChem CID: 182140 Isomeric SMILES: COC[C@@H]1CC2=CC(=C3C(=C2[C@@H]([C@H]1COC)C4=CC(=C(C=C4)OC)OC)OCO3)OC
- UPC:
- 51112608
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- H649860-1mg
- CAS:
- 33676-00-5
- Product Size:
- 1mg
