InformationIDF-11774 IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.TargetsHIF-1In vitroIDF-11774 inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells under hypoxic conditions. The treatment of IDF-11774 suppresses angiogenesis of cancer cells by reducing the expression of HIF-1 target genes, reduces glucose uptake, thereby sensitizing cells to growth under low glucose conditions, and decreases the extracellular acidification rate (ECAR) and oxygen consumption rate of cancer cells. Therefore, IDF-11774 reduces cancer cell growth through the regulation of cancer glycolytic metabolism and energy production.In vivoIDF-11774 exhibited substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations, which often occur in malignant cancers.Cell Research(from reference)Cell lines：HCT116 cells Concentrations：5, 10, 20 μM Incubation Time：18 h. Specification: 0.99 Molecular Formula: C23H32N2O2 Molecular Weight: 368.51 PubChem CID: 71542096 Isomeric SMILES: CN1CCN(CC1)C(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/I414168-SCI_adb6d672a7de2e70f45c303dbcecd25f.pdf
- UPC:
- 12352200
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.97 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- I414168-50mg
- CAS:
- 1429054-28-3
- Product Size:
- 50mg
- Hazard Statement Codes:
- H302:H315:H319:H335
- Precautionary Statement Codes:
- P261:P305+P351+P338
