Antigen: synthetic peptide containing phosphorylated serine residues corresponding to human IκBα amino acids 32 and 36 Host: mouse, clone 39A1413 Isotype: IgG1κ Cross Reactivity: (+) bovine, canine, human, mouse, porcine, and rat IκBα Application(s): WB and IP External stimuli such as tumor necrosis factor or other cytokines initiates a signal transduction cascade that leads to activation of the IκB-kinase complex that specifically phosphorylates IκBα on serine32 and serine36. Phosphorylation of these sites leads to ubiquitination of IκBα and subsequent degradation by the 26S proteasome. Degradation of IκBα results in unmasking of the nuclear localization signal of NF-κB dimers, which subsequently translocate to the nucleus and activate target genes.
- UPC:
- 12350000
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 13923-1
