IL-33 Mouse mAb (C09-0739-664)

Mouse anti Human IL-33 Antibody, Monoclonal antibody (C11), could be used for WB, IHC and so on.ApplicationWB: 0.01-3µg/mLIHC: 5-30µg/mL Protein FunctionCytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation. Specifications and Purity: mAb (C11); Mouse anti Human IL-33 Antibody; WB, IHC; Unconjugated.