Ilexgenin A (C09-1140-000)

Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer.In VitroIlexgenin A (0~100 μM; 24 hours; HT 29 and HCT 116 cells) effectively decreases cell viability in HT 29 and HCT 116 cells. Ilexgenin A (12.5~50 μM; 24 hours; HT 29 cells) downregulates the expression of SREBP-1, inhibits the translocation of SREBP-1 to the nucleus and decreases the content of TG. Ilexgenin A (12.5~50 μM; HT 29 and HCT 116 cells) induces cell cycle arrest at G1 phase in colon cancer cells. Ilexgenin A (12.5~50 μM; 24 hours; HCT 116 cells) modulates lipid metabolism. Ilexgenin A (50 μM; 24 hours; HT 29 and HCT 116 cells) regulates SREBP-1 by inhibiting HIF1α. Ilexgenin A inhibits fatty acids synthesis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HT 29 and HCT 116 cells Concentration: 0~100 μM Incubation Time: 24 hours Result: Effectively decreased cell viability in HT 29 and HCT 116 cells. Western Blot AnalysisCell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Downregulated the expression of SREBP-1. RT-PCRCell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Decreased the content of TG. ImmunofluorescenceCell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Inhibited the translocation of SREBP-1 to the nucleus.In VivoIlexgenin A (20 mg/kg) ameliorates the AOM/DSS induced carcinogenesis. Ilexgenin A can regulate lipid metabolism. Ilexgenin A decreases the expression of SREBP-1 and HIF 1α in AOM/DSS mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid. Specification: 0.98 Molecular Formula: C30H46O6 Molecular Weight: 502.7 PubChem CID: 21672638 Isomeric SMILES: C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)C(=O)O)O)C)C)[C@@H]2[C@]1(C)O)C)C(=O)O