IM-12

Catalog No.: C005B-313811
Mfr. No.: SML0084-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $319.17

List Price: $354.63

Biochem/physiol Actions IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β: (GSK-3β:) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increased β:-catenin

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Biochem/physiol Actions

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. It has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.

UPC:: 51182031
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML0084-5MG
CAS:: 1129669-05-1

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