Imidazolo-oxindole PKR inhibitor C16 (C15-1252-219)

Sigma-Aldrich

Catalog No.: C15-1252-219
Manufacturer No.: I9785-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Price: $718.29

List Price: $798.10

Application Imidazolo-oxindole PKR inhibitor C16 has been used: to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid

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Description
Specifications

Application

Imidazolo-oxindole PKR inhibitor C16 has been used:

to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice
to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid transfection in HeLa-S3 cells
to augment eukaryotic translation initiation factor 2 (eIF2) activity

Biochem/physiol Actions

C16 exhibits a neuroprotective role in adult brain injuries.

Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.

UPC:: 12352200
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: I9785-25MG

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