IMMOBILIZED HEPARIN, 5ML

G-Biosciences Immobilized Heparin is a ready-to-use purification resin for a wide range of proteins.The resin consists of 6% cross-linked agarose covalently coupled to heparin through amide bonds.The coupling chemistry used generates a highly stable purification resin that is stable most commonly used buffers and denaturants. Heparin is a linear glycosaminoglycan composed of equimolar quantites of glucosamine and glucuronic acid, alternatively linked by α(1→4) glycosidic bonds.A number of its hydroxyl groups are esterified with sulfuric acid moieties and the molecule has a single reducing sugar terminus. Due to its structure and biochemical role, Heparin is able to bind a number of proteins, enzymes and polycationic organic compounds.The binding is either ionically or more specific protein-ligand or enzyme-inhibitor (or enzyme-activator) interactions. Several classes of proteins can bind to heparin, including: Coagulation Factors : ATIII, Factors IX, VII, XI, XII and XIIa Lipoprotein Lipases : By ionic interactions Lipoproteins : LDL, VLDL, VLDL apoprotein, HDL Growth Hormones Growth Factors : FGF, ECGF DNA- & RNA- Related Enzymes : Polymerases, nucleases, endonucleases Enzymes : Including collagenase, hyaluronidase, lysozyme, proteases Click here to request bulk or custom sizes .