An anti-proliferative and anti-angiogenic compound. IMS2186 is a novel synthetic compound developed as an anti-CNV drug. The proposed mechanism of action under investigation, is blocking the cell cycle at G2 and inhibiting the production of PGE2/TNF-α. The latter contributing to anti-angiogenic and antiinflammatory effects. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50= 0.1 μM) and cell migration, which plays a role in many biological processes: inflammation, angiogenesis, and scar formation. The physicochemical structure of IMS2186 showed also that the free drug concentration in a physiological media (e.g., vitreous or saline) is 8-10 μM above the IC50 for all these activities (0.1-3.0 μM). Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss. Molecular Formula: C18H16O4 Molecular Weight: 296.32 PubChem CID: 24987039 Isomeric SMILES: CC1=CC2=C(C=C1)OC/C(=C/C3=CC(=C(C=C3)OC)O)/C2=O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/I340151-SCI_6bdf1cdff691341c9c44216fedcb6087.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- I340151-25mg
- CAS:
- 1031206-36-6
- Product Size:
- 25mg
- Hazard Statement Codes:
- H400
- Precautionary Statement Codes:
- P273:P391:P501
