INCB059872 dihydrochloride (C09-1140-589)

INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 ( LSD1 ) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia.Appearance:SolidIC50& Target:KDM1/LSD1In Vitro:INCB059872 (25 nM; 48 hours; 293T cells) dihydrochloride increases enhancer activity and gene expression. INCB059872 (25 nM; 24 hours; THP-1 cells) dihydrochloride makes THP-1 show a growth defect within one cell doubling time or approximately 3 daysIn Vivo:INCB059872 (10mg/kg; p.o.; 0, 4, or 6 days; C57BL/6J mice) dihydrochloride makes single-cell RNA-seq revealing changes in bone marrow progenitor populations. MCE has not independently confirmed the accuracy of these methods. They are for reference oBiological Activity:INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 ( LSD1 ) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia. Specification: 0.98 Molecular Formula: C23H36Cl2N2O3 Molecular Weight: 459.45