Inhibitor of PI3K and microtubule polymerization. It induces cell cycle arrest, polyploidy, and apoptosis in glioblastoma cells and suppresses invasiveness of squamous cell lung cancer cells. (C08-0489-144)

Thomas Scientific

Catalog No.: C08-0489-144
Manufacturer No.: B4248-5 mg
Manufacturer Name: LKT Laboratories, Inc
Quantity: 1
Unit of Measure: EA

Price: $359.86

List Price: $399.85

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Description
Specifications

BKM120 is an inhibitor of PI3K that is currently in clinical trials as a potential treatment for brain metastases of HER2+ breast cancer and other solid tumors. BKM120 exhibits anticancer chemotherapeutic and anti-metastatic activities, inducing G2/M phase cell cycle arrest, polyploidy, and apoptosis in glioblastoma cells. Additionally, BKM120 decreases levels of Mcl-1 and enhances TRAIL-dependent apoptosis in lung cancer cells. BKM120 also binds tubulin, inhibiting microtubule polymerization. This compound prevents invasion and epithelial-to-mesenchymal transition (EMT) in cellular and animal models of squamous cell lung cancer.

UPC:: 41122409
Condition:: New
Availability:: 3 Days
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: B4248-5 mg
CAS:: 944396-07-0

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