General description
A cell-permeable, irreversible, and general caspase inhibitor. Also reported to inhibit Peptide: N-glycanase (PNGase) in vitro and in vivo. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
general caspase inhibitor
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Sequence
Z-Val-Ala-Asp-CH₂F*
Physical form
A 10 mM (1 mg/221 µl) solution of Caspase Inhibitor VI (Cat. No. 219007) in DMSO.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.
Other Notes
Misaghi, S., et al. 2004. Chem. Biol.11, 1677.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51283102
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 219011-1MG