General description
A cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Inhibitor of microfilament-mediated processes in sperm, eggs, and embryos
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Harmful (C)
Physical form
A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428021 in DMSO.
Reconstitution
Following initial use, aliquot and freeze (-20°C).
Other Notes
Ayscough, K.R., et al. 1997. J. Cell Biol.137, 399.
Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Schatten, G., et al. 1986. Exp. Cell Res.166, 191.
Spector, I., et al. 1983. Science219, 493.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 421.55. Empirical Formula: C22H31NO5S. Quality Level: 100. Assay: ≥. 85% (HPLC). form: liquid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, desiccated (hygroscopic), protect from light. shipped in: wet ice. storage temp.: −. 20°C. Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): 188.6 °F - (refers to pure substance). Flash Point(C): 87 °C - (refers to pure substance).- UPC:
- 51284131
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 428026-50UG
