INSOLUTION RAPAMYCIN - CALBIOCHEM (C005B-230007)

General description

Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC₅₀ = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Mammalian target of rapamycin (mTOR)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.

Reconstitution

Following initial use, aliquot and freeze (-20°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 914.17. Empirical Formula: C₅₁H₇₉NO₁₃. Quality Level: 100. Assay: ≥. 95% (HPLC). form: solution. manufacturer/tradename: Calbiochem^®. . storage condition: desiccated (hygroscopic), protect from light. shipped in: wet ice. storage temp.: −. 20°C. Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): 188.6 °F - (Dimethylsulfoxide). Flash Point(C): 87 °C - (Dimethylsulfoxide).

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