General description
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µM and 38 µM, respectively).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
ySir2
Product does not compete with ATP.
Reversible: no
Target IC50: 48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Physical form
A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.
Reconstitution
Following initial thaw, aliquot and refrigerate (4°C).
Other Notes
Mai, A., et al. 2005. J. Med. Chem.48, 7789.
Grozinger, C.M., et al. 2001. J. Biol. Chem.276, 38837.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 394.47. Empirical Formula: C26H22N2O2. Quality Level: 100. Assay: ≥. 97% (HPLC). form: liquid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, desiccated (hygroscopic), protect from light. shipped in: wet ice. storage temp.: 2-8°C. Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): 188.6 °F - (Dimethylsulfoxide). Flash Point(C): 87 °C - (Dimethylsulfoxide).- UPC:
- 51284307
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 566321-1MG
