General description
A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen in ethanol.
A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Estrogen receptor
Warning
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Physical form
A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen (Cat. No. 579002) in EtOH.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only anhydrous, 200 proof ethanol for further dilutions.
Other Notes
Gundimeda, U., et al. 1996. J. Biol. Chem.271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health4, 364.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51111873
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 5082250001