General description
A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM. The solid form of this compound (Cat. No. 200484) is also available.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Metalloproteases
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Physical form
Supplied as a 50 mM (10 mg/580 µL) solution of Bestatatin, HCl in H₂O.
Reconstitution
Following initial, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Other Notes
Merck Index: 14, 9842.
Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab.79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51283722
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 200488-10MG
