Interleukin-13, Human, Recombinant, E. coli

General description

Recombinant, human interleukin-13 expressed in E. coli. Pleiotropic cytokine that shares many of the properties of IL-4. Exhibits IL-4-like activities on monocytes/macrophages and human B cells but has no effect on T cells. A potent regulator of STAT6 and JAK3 in NK and T cells. Regulates inflammatory and immune responses. Inhibits inducible nitric oxide synthase in human mesangial cells.

Recombinant, human interleukin-13 expressed in E. coli. Pleiotropic cytokine that shares many of the properties of IL-4. Exhibits IL-4-like activities on monocytes/macrophages and human B cells but has no effect on T cells. Potent regulator of inflammatory and immune responses. Inhibits inducible nitric oxide synthase in human mesangial cells.

Biochem/physiol Actions

ED₅₀ = 0.5-2.5 ng/ml as measured in a cell proliferation assay using a human factor-dependent cell line, TF-1

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from sterile-filtered PBS, pH 7.4.

Reconstitution

Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.

Reconstitute to a concentration of ≥5 µg/ml with sterile PBS.

Other Notes

Yu, C.R., et al. 1998. J. Immunol. 161, 218.
Saura, M., et al. 1996. Biochem. J. 313, 641.
Xi, X., et al. 1995. Br. J. Haematol. 90, 921.
Zurawski, G., and DeVries, J.E. 1994. Stem Cells 12, 169.
McKenzie, A.N.J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3735.
Minty, A., et al. 1993. Nature 362, 248.

Legal Information

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