Interleukin-2; Human IL-2, 10ug

IL-2, Interleukin-2, human: Human Interleukin-2 Interleukin 2 is a protein that has a variety of immunologic functions, the most notable being the ability of IL-2 to promote the proliferation and maturation of activated T cells. A comparison of the amino acid sequences of human and murine IL-2 shows an approximately 60% sequence similarity, and human sequence IL-2 has been found to be active on murine cell lines. Some of the biological activities attributed to IL-2 include: induction of secretion of interferon-γ and tumor necrosis factors -α and -β from peripheral blood mononuclear cells stimulation of the rate of synthesis of c-myc RNA and transferrin receptor activation of neutrophils stimulation of proliferation and maturation of activated helper T cells stimulation of proliferation of activated and natural killer cells and tumor-infiltrating lymphocytes, as well as enhancement of the ability of these cytotoxic lymphocytes to kill target cells induction of the expression of IL-2 receptors on T cells stimulation of proliferation of antibody-producing B cells Source: Escherichia coli. Molecular Weight: Approximately 15 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids. Quantity: 10ug/50ug/1000µg Purity: >97% by SDS-PAGE and HPLC analyses. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of murine CTLL-2 cells is less than 0.1 ng/ml, corresponding to a specific activity of > 1 x 107 units/mg. Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder. Formulation: Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.5. AA Sequence: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLT Endotoxin: Less than 1EU/mg of rHuIL-2 as determined by LAL method.