INY-03-041 trihydrochloride is a potent, highly selective and PROTAC-based pan- AKT degrader consisting of the ATP-competitive AKT inhibitor Ipatasertib ( HY-15186 ) conjugated to Lenalidomide (HY-A0003, Cereblon ligand). INY-03-041 trihydrochloride inhibAppearance:SolidIC50& Target:Akt1 2.0 nM (IC 50 ) Akt3 3.5 nM (IC 50 ) Akt2 6.8 nM (IC 50 ) CereblonIn Vitro:INY-03-041 (10-1000 nM; 0-24 hours) induces potent degradation of all three AKT isoforms in MDA-MB-468 cells. INY-03-041 exhibits potent in vitro inhibition of S6K1 (IC 50 =37.3 nM) and PKG1 (IC 50 = 33.2 nM). INY-03-041 displays enhanced anti-pBiological Activity:INY-03-041 trihydrochloride is a potent, highly selective and PROTAC-based pan- AKT degrader consisting of the ATP-competitive AKT inhibitor Ipatasertib ( HY-15186 ) conjugated to Lenalidomide (HY-A0003, Cereblon ligand). INY-03-041 trihydrochloride inhib. Specification: 0.99 Molecular Formula: C44H59Cl4N7O5 Molecular Weight: 907.8
- UPC:
- 51162609
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- I659395-1mg
- Product Size:
- 1mg
