IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx ( K d =2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease HBx: hepatitis B virus X protein.In VitroHepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of viral genes. IR415 (50-200 μM) has a dose-dependent inhibitory effect on HBx, with a minimal effective concentration of 50 μM in HepG2/GFP-shRNA line transfected with HBx. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Kd: 2 nM (IR415-HBx interaction). Specification: 0.98 Molecular Formula: C13H14F2N4S Molecular Weight: 296.34 PubChem CID: 2824621 Isomeric SMILES: C1=CC(=C(C=C1F)F)NC(=S)NCCCN2C=CN=C2
- UPC:
- 51201607
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- I650285-10mg
- CAS:
- 452967-14-5
- Product Size:
- 10mg
